Biomira documents NDA for novel inhibitor of hypoxia-inducible factor-1 alpha Biomira Inc.

Kirkman, M.D., Chief and President Executive Officer of Biomira. Upon clearance of the IND, we plan to initiate a Stage 1 trial because of this compound in the 3rd quarter of 2007. We are also on track to progress our other pipeline applications, including initiating another Stage 2 trial for PX-12 and filing an IND for PX-866 by the finish of the year. At that time we could have four applications in clinical development, reflecting the guarantee and diversity of the product pipeline. PX-478 can be a powerful inhibitor of HIF-1 alpha, a protein focus on whose amounts are elevated in an array of tumors. The proteins is a key element in the response of a cancer tumor cell to hypoxia , like the angiogenic cascade which allows tumors to determine new blood vessels necessary to their survival and development.High levels of Met-Enk cause pets to drink much less. Related StoriesCharles Bonnet syndrome: an interview with Dr. The antisense inhibited the brain’s production of Met-Enk and, as predicted, the pets drank more, says Banking institutions, who also is an employee doctor at Veterans Affairs Medical Center in St. Louis. We found that the antisense molecules, especially when provided as a cocktail of three antisense compounds, decreased Met-Enk in the mind and increased alcoholic beverages drinking. The study is important in studying alcoholism, Banks says. This is a new level of proof that Met-Enk is certainly involved with alcohol drinking, seizures, and maybe alcoholism and alcoholic beverages withdrawal seizures, he says.

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