These factors include academic difficulties, family problems, biological aspects, and also social problems. With this in mind, it is crucial for parents to be aware of the indicators of depression in kids so as to quickly evaluate if their kids are suffering from it. The following are some of the important things that parents should know if they suspect that their children might be suffering from anxiety and depression: Ask questions the right way. Kids are children. So parents have to talk with their children the right way. When asking queries, better do it in a gentle way. Ask your child if he or she is having troubles at school or when there is something at home that troubles or saddens her or him. Observe frequent crying or tantrums.Knowledge of this genomic change is then used to design a therapeutic strategy aimed specifically at that molecular defect, such as the anti-Tau antibody for PSP. Beneath the conditions of the agreement, Bristol-Myers Squibb has acquired most of iPierian's issued and outstanding shares of capital share and all common share equivalents in an all cash deal for a purchase price of $175 million, with the potential for additional development and regulatory milestone payments totaling $550 million, along with future royalties on net sales.